BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

OBJECTIVES: Early-emerging, temperamental differences in fear-related traits may be a heritable vulnerability factor for anxiety disorders. Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits. METHODS: Associations between 5-HTTLPR genotype and indices of fearful child temperament, derived from maternal report and standardized laboratory observations, were examined in a community sample of 95 preschool-aged children. RESULTS: Children with one or more long alleles of the 5-HTTLPR gene were rated as significantly more nervous during (...) standardized laboratory tasks than children who were homozygous for the short alleles. Children homozygous for the short alleles were also rated as significantly shyer, by maternal report, than those with at least one copy of the long allele of the 5-HTTLPR gene. CONCLUSIONS: This study extends the literature linking the short alleles of the serotonin transporter promoter region polymorphism to fear and anxiety-related traits in early childhood and adulthood, and is one of very few studies to examine the molecular genetics of preschoolers' temperament using multiple measures of traits in a normative sample. (shrink)

There are many important methodological decisions that need to be made when examining emotional reactivity in psychopathology. In the present study, we examined the effects of two such decisions in an investigation of emotional reactivity in depression: (1) which (if any) comparison condition to employ; and (2) how to define change. Depressed (N = 69) and control (N = 37) participants viewed emotion-inducing film clips while subjective and facial responses were measured. Emotional reactivity was defined using no comparison condition (i.e., (...) raw scores), baseline comparison condition (i.e., no stimulus presented), and neutral comparison condition (i.e., neutral stimulus presented). Change in emotional reactivity was assessed using four analytic approaches: difference scores, percentage change, residualised change, and ANCOVA. Results differed among the three comparison conditions and among several of the analytic approaches. Overall, our investigation suggests that choosing a comparison condition and the definition of change can significantly influence the presence of group differences in emotional reactivity. Recommendations for studies of emotional reactivity in psychopathology are discussed. (shrink)

Lagrangian formulation of quantum mechanical Schrödinger equation is developed in general and illustrated in the eigenbasis of the Hamiltonian and in the coordinate representation. The Lagrangian formulation of physically plausible quantum system results in a well defined second order equation on a real vector space. The Klein–Gordon equation for a real field is shown to be the Lagrangian form of the corresponding Schrödinger equation.

Cet ouvrage est l'hommage qu'une des deux filles de Jean Klein (1912-1998), Nita, comédienne et artiste, a décidé de rendre à son père, un des plus célèbres maîtres spirituels du XXe siècle, pour le centième anniversaire de sa naissance. Nita Klein a rassemblé ici de nombreux souvenirs de conversations avec Jean Klein, des inédits, des photographies autour de la question de l'art et de la spiritualité. Jean Klein a été philosophe et un maître spirituel remarquable auteur (...) d'une oeuvre essentielle qui a infuencé de nombreux enseignants contemporains comme Eric Baret, Jean-Bouchart D'Orval, Francis Lucille, Jean-Marc Mantel etc. Même si Jean Klein n'appartenait à aucune école, sa quête de la vérité a rencontré l'Advaïta Vedânta (Non-Dualité) dont il a dit lui-même que " ce n'est pas un système, une religion, une technique. Ce n'est même pas une philosophie, c'est simplement la vérité. " Mais Jean Klein était aussi violoniste (il pratiqua toute sa vie le violon) et s'intéressait à toutes les formes d'art : au théâtre, à la peinture (il était ami de Hans Hartung), à la danse (son autre fille, Malavika, est professeur de danse indienne). Il s'agit donc dans ce livre d'une rencontre entre l'intuition d'un artiste et la recherche indienne de la vérité, recherche plus orientée vers la perception globale de la Réalité que vers les certitudes offertes par le savoir. Nita Klein nous invite à découvrir comment la spiritualité authentique conduit à la création artistique ; comment, dans l'art du théâtre, l'interprétation d'un personnage, peut atteindre à la vérité, quand la personnalité du comédien consent à s'effacer. " En l'absence du "Moi", il y a seulement la vie. ", dit Jean Klein. Et pas seulement dans le théâtre, mais dans la peinture, le dessin, la danse. La Non-Dualité, avec Jean Klein, est une ouverture à la Beauté. (shrink)

I. Les facultés qui se rapportent à l'image des objets en nous, — l'imagination au sens large, — constituent, selon une tradition qui vient d'Aristote, l'intermédiaire entre la sensibilité et l'intellect. Le moyen âge les désigna par le nom de sens intérieurs ; leur liste fut reprise et modifiée par Ficin (dont la source directe n'est pas Avicenne, mais Albert le Grand) et par Bruno. Dans l'interprétation des néoplatoniciens, la série des facultés connaissantes représente le chemin de l'âme dans la (...) conversion ; la phantasia y joue un rôle eminent (Plotin, Hugues de Saint-Victor, Ficin, Bruno) ; d'autre part, on fait correspondre à la faculté intermédiaire une âme intermédiaire qui lui sert de substrat (Lulle), et un « premier corps » ou « véhicule » de l'âme (le spiritus phantasticus ou őχημα-πνεῦμα de Synesius). L'idée reparaît, modifiée, chez Hugues de Saint-Victor, Ficin, Bruno. Ce dernier met le spiritus phantasticus en relation avec l'âme du monde, qui lui est consubstantielle, la « lumière précédant toute Création » qui nous fait voir les images de nos rêves. Sources : Porphyre, Cusanus repris par Ficin, le panthéisme médiéval. Le lien entre le spiritus phantasticus et le destin de l'âme, esquissé chez Plotin, Porphyre, le Pseudo-Jamblique, Synesius, est affirmé sous différentes formes par Hugues, Ficin et Bruno : le sujet des peines infernales, qui sont d'ailleurs chez Ficin et Bruno de nature imaginaire, est un corps subtil. Ces peines correspondent exactement à ce que nos appétits et notre imagination ont fait de la substance de notre âme. Le spiritus phantasticus se rapproche, notamment chez Ficin, d'une sorte de karma. II. Dans la branche descendante de la connaissance, l'application de l'universel au particulier est forcément liée au sens intérieur et on l'attribue à une faculté spéciale, la Urteilskraft au sens kantien. Bruno en fait une fonction de l'imagination. D'autre part, les arts universels ou lulliens ont pris de plus en plus, durant la Renaissance, l'aspect de topiques généralisées ; le nerf de la méthode y était donc toujours cette Urteilskraft. Il s'en suit, chez Bruno, que le sujet de l'art universel est l'imagination, qui devient ainsi la source première de tout acte de l'intellect, principe de la fécondité infinie de la pensée. (Pratiquement, d'ailleurs, les artes de Bruno sont des ensembles d'images). III. Aux théories de l'imagination répondent les théories de l'image, « vêtement » et « premier corps » de la pensée. On vérifie cette correspondance, d'une part, dans la théorie du symbole, — avec ses variantes métaphysiques, pansymbolisme, magie, — et, d'autre part, dans celle du concetto (rapport entre la pensée et l'expression), où l'on va jusqu'à l'idée d'un universel de l'imagination, et du dessin comme concept. — Une importante différence entre la nature du symbolisme selon Pic et l'idée que s'en fait Bruno s'explique par leurs conceptions différentes de l'imagination. La théorie de l'art et l'évolution du goût artistique sont, dans leurs grandes lignes, en concordance avec ce qu'impliquent ou suggèrent à ce sujet les théories de l'imagination et de l'image. (shrink)

The Schrödinger equation for a particle of rest mass $m$ and electrical charge $ne$ interacting with a four-vector potential $A_i$ can be derived as the non-relativistic limit of the Klein–Gordon equation $\left( \Box '+m^2\right) \varPsi =0$ for the wave function $\varPsi $ , where $\Box '=\eta ^{jk}\partial '_j\partial '_k$ and $\partial '_j=\partial _j -\mathrm {i}n e A_j$ , or equivalently from the one-dimensional action $S_1=-\int m ds +\int neA_i dx^i$ for the corresponding point particle in the semi-classical approximation $\varPsi (...) \sim \exp {(\mathrm {i}S_1)}$ , both methods yielding the equation $\mathrm {i}\partial _0\varPsi \approx \left( \frac{1}{2m}\eta ^{\alpha \beta }\partial '_{\alpha }\partial '_{\beta } + m + n e\phi \right) \varPsi $ in Minkowski space–time , where $\alpha ,\beta =1,2,3$ and $\phi =-A_0$ . We show that these two methods generally yield equations that differ in a curved background space–time $g_{ij}$ , although they coincide when $g_{0\alpha }=0$ if $m$ is replaced by the effective mass $\mathcal{M}\equiv \sqrt{m^2-\xi R}$ in both the Klein–Gordon action $S$ and $S_1$ , allowing for non-minimal coupling to the gravitational field, where $R$ is the Ricci scalar and $\xi $ is a constant. In this case $\mathrm {i}\partial _0\varPsi \approx \left( \frac{1}{2\mathcal{M}'} g^{\alpha \beta }\partial '_{\alpha }\partial '_{\beta } + \mathcal{M}\phi ^{(\mathrm g)} + n e\phi \right) \varPsi $ , where $\phi ^{(\mathrm g)} =\sqrt{g_{00}}$ and $\mathcal{M}'=\mathcal{M}/\phi ^{(\mathrm g)} $ , the correctness of the gravitational contribution to the potential having been verified to linear order $m\phi ^{(\mathrm g)} $ in the thermal-neutron beam interferometry experiment due to Colella et al. Setting $n=2$ and regarding $\varPsi $ as the quasi-particle wave function, or order parameter, we obtain the generalization of the fundamental macroscopic Ginzburg-Landau equation of superconductivity to curved space–time. Conservation of probability and electrical current requires both electromagnetic gauge and space–time coordinate conditions to be imposed, which exemplifies the gravito-electromagnetic analogy, particularly in the stationary case, when div ${{\varvec{A}}}=\hbox {div}{{\varvec{A}}}^{(\mathrm g)}=0$ , where ${{\varvec{A}}}^{\alpha }=-A^{\alpha }$ and ${{\varvec{A}}}^{(\mathrm g)\alpha }=-\phi ^{(\mathrm g)}g^{0\alpha }$ . The quantum-cosmological Schrödinger (Wheeler–DeWitt) equation is also discussed in the $\mathcal{D}$ -dimensional mini-superspace idealization, with particular regard to the vacuum potential $\mathcal V$ and the characteristics of the ground state, assuming a gravitational Lagrangian $L_\mathcal{D}$ which contains higher-derivative terms up to order $\mathcal{R}^4$ . For the heterotic superstring theory , $L_\mathcal{D}$ consists of an infinite series in $\alpha '\mathcal{R}$ , where $\alpha '$ is the Regge slope parameter, and in the perturbative approximation $\alpha '|\mathcal{R}| \ll 1$ , $\mathcal V$ is positive semi-definite for $\mathcal{D} \ge 4$ . The maximally symmetric ground state satisfying the field equations is Minkowski space for $3\le {\mathcal {D}}\le 7$ and anti-de Sitter space for $8 \le \mathcal {D} \le 10$. (shrink)

This paper looks into the known evidence on the origins of the type of argument called the circumstantial ad hominemargument in modern logic textbooks, and introduces some new evidence. This new evidence comes primarily from recent historical work by Jaap Mansfeld and Jonathan Barnes citing many cases where philosophers in the ancient world were attacked on the grounds that their personal actions failed to be consistent with their philosophical teachings. On the total body of evidence, two hypotheses about the roots (...) of the circumstantial ad hominem are considered. One is that it came from Aristotle through Locke. The other is that it may have had separate roots in these ancient philosophical writings that criticized philosophers for not practicing what they preached. (shrink)

На основе детальной реконструкции идей Канта в книге прослеживается генезис трансцендентальной телеологии, возможность соединения в единое целое теоретической и практической функции разума и дается полное проблемное описание концептуального аппарата.

T. 1. Metodologicheskie osnovanii︠a︡ i modeli, Bogopoznanie i nauchnoe znanie -- t. 2. Chislo. Garmonii︠a︡. Metafizika Sveta -- t. 3. Svet bogoslovskie osnovanii︠a︡ kreatologi.

Of all the distinctive features of the Buddhist religion, one of the most neglected is the sangha . Scholars give much attention to the study of texts and commentaries, the analysis of doctrines and the classification of schools. But the core of the Buddhist religion is the sangha , the community of bhikkhus around whose corporate life the religion is moulded. It is the existence and structure of the sangha which has shaped the history of Buddhism, enabled it to take (...) root in new countries, and given it the customs and rituals which have made it a religion rather than a small sect. (shrink)

ABSTRACT The much discussed ethical problems of clinicians, who have direct care of patients, are mainly within their responsibilities to the ‘index’patient with whom they are immediately concerned. When pathologists are practising clinical pathology they are responsible for performing and interpreting tests on specimens from patients at the request of clinicians, and advising on these tests. Their ethical problems, as they do not have direct care of patients, mainly lie between their obligations to the requesting clinician, to the index patient (...) under investigation in the laboratory, and also to other patients, and to their staff. These problems are largely ignored in the literature both of medical ethics and of pathology. The ethical principles of: (1) respect for autonomy; (2) non‐maleficence; (3) beneficence; and (4) justice are discussed with particular reference to the work of clinical pathologists: possible applications of virtue ethics are also considered. Ethical problems that arise in the course of a pathologist's receiving, investigating, and reporting and advising on, a patient's specimen are examined on the basis of the above principles: an attempt is made to offer guidance on the problems. (shrink)

D. N. MacCormick; XI*—The Obligation of Reparation, Proceedings of the Aristotelian Society, Volume 78, Issue 1, 1 June 1978, Pages 175–194, https://doi.org/10.

Objectives: To describe the concerns and priorities of key stakeholders in a developing country regarding ethical obligations held by researchers and perceptions of equity or “what is fair” for study participants in an HIV/AIDS clinical drug trial. Design: Qualitative study with focus groups. Setting: Teaching and referral hospital and rural health centre in western Kenya. Participants: Potential HIV/AIDS clinical trial participants, clinician researchers, and administrators. Results: Eighty nine individuals participated in a total of 11 focus groups over a four month (...) period. The desire for continued drug therapy, most often life long, following an HIV/AIDS clinical trial was the most common priority expressed in all focus groups. Patients with and without HIV/AIDS also thought subsidisation of drug therapies and education were critical forms of compensation for clinical trial participation. Financial incentives were considered important primarily for purchasing drug therapy as well as obtaining food. Patients noted a concern for the potential mismanagement of any money offered. Clinician researchers and administrators felt strongly that researchers have a moral obligation to participants following a trial to provide continued drug therapy, adverse event monitoring, and primary care. Finally, clinician researchers and administrators stressed the need for thorough informed consent to avoid coercion of study participants. Conclusions: Kenyan patients, clinician researchers, and administrators believe that it would be unfair to stop antiretroviral therapy following an HIV/AIDS clinical trial and that researchers have a long term obligation to participants. (shrink)